The AccuTOF LC-plus 4G, the third generation of the successful AccuTOF LC series, is a simple, robust and versatile atmospheric pressure ionization high-resolution time-of-flight mass spectrometer (API-HRTOFMS). It can provide solutions for a wide variety of fields with JEOL’s unique ionization technologies, DART and ColdSpray, in addition to the standard electrospray ionization (ESI), the most widely used ionization technique for LC/MS.